The Gravity star was joined on stage by three of her leading men, Matthew McConaughey, Keanu Reeves and Hugh Grant, as she picked up the award, a bling tiara, sash and a bouquet of red roses.
The 49-year-old actress chose a hot pink strapless mini dress and black strappy sandals to collect the honour, wearing her hair in loose waves.
Bullock joked with her former co-stars on stage, appearing to bow in front of them, and gave Grant a hug before he had handed over the award, a set of gold ‘mantlers’.
Spike TV describes the Guys Choice awards as everything a typical award is not – calling it “a hilarious, unpretentious, heartfelt event where comedy is king and the world’s greatest stars (past and present) align to toast the mega-spendour of all things GUY.”
McConaughey, who starred alongside Bullock in 1996’s A Time To Kill, won the Guy Of The Year award at the star-studded event, which was also attended by his wife Camila Alves, Aaron Paul, Andy Samberg, Cameron Diaz, Mark Wahlberg, and Jessica Alba.